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Clare M. Wieland

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Open access Sep 2026

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation

Abstract Intronic GGGGCC repeat expansions in C9orf72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This expansion supports a non-canonical form of translational initiation known as repeat-associated non-AUG (RAN) translation to produce toxic dipeptide repeat proteins that contribute to n...

Clare M. Wieland, Shannon E. Wright, Sydney Willey et al. · 0 citations

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