Open access
Aug 2026
Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection
It is found that the accumulation of mutations was slower than expected, implying a selection against HIV-1 diversification in acute infection, potentially leaving a window of low genetic diversity for the study of new interventions towards inducing viremic control, such as immunotherapy or mRNA vaccination.
A. Capoferri, V. Boltz, W. Shao et al.
· bioRxiv · 0 citations