Author

Claudia Höbartner

3 papers indexed here

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Open access Sep 2026

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

ABSTRACT Site‐specific labeling of RNA with emissive, structurally non‐perturbing nucleosides is critically needed for probing RNA structure, dynamics, and function. Isothiazolopyrimidine‐based nucleoside surrogates are leading examples of fluorescent RNA building blocks, with the C‐nucleosidic guanosine analogue tzG s...

Julia Dietzsch, Y. Tor, Claudia Höbartner · Angewandte Chemie · 0 citations

Open access Aug 2026

Guanosine 10 methylation by TRMT11–TRMT112 optimizes human mitochondrial tRNAs for efficient translation

Abstract Modified nucleotides are essential determinants of RNA function, and identifying the enzymes that install them is fundamental to understanding their cellular roles. Here, we show that the human RNA methyltransferase TRMT11 and its cofactor TRMT112 are imported into mitochondria via N-terminal targeting signals...

Jonny Petrosyan, Mehmet Yilmaz, Carolin P. M. Scheitl et al. · Nucleic Acids Research · 0 citations

Open access Jul 2026

A magic methyl effect in the active site of a methyltransferase ribozyme

This work pinpointed how 2’-O-methylation of active site nucleotides synergistically enhance ribozyme activity by reducing ribose rings’ conformational flexibility by reducing ribose rings’ conformational flexibility.

Jana Aupič, Hsuan-Ai Chen, Carolin P. M. Scheitl et al. · Nature Communications · 0 citations