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Claudia Stäubert

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Open access Sep 2026

Energy Landscape Sampling Reveals Ligand-Dependent Structural Dynamics of the Protease-Activated Receptor 1

Protease-activated receptor 1 (PAR1) is a class A G protein-coupled receptor activated by proteolytic cleavage and exposure of a tethered agonist. While existing structures have revealed inactive and active conformations, the ligand-dependent conformational energy landscape governing PAR1 activation remains poorly un...

Inken Kaja Schwerin, Shi-Hai Jiang, Claudia Stäubert et al. · 0 citations

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