Open access
Aug 2026
Honokiol-mediated reversal of cisplatin-induced transcriptomic changes in outer hair cells.
Cisplatin-induced hearing loss (CIHL) affects half a million cancer patients annually, but treatment strategies are limited. We have previously shown that honokiol, an antioxidant and otoprotective compound, upregulates mitochondrial sirtuin 3 (SIRT3) and protects against CIHL. In the present study, we investigated the...
Chail Koo, Robert J Fuentes, Prerita Pandya et al.
· Biomedicine & pharmacotherap... · 0 citations