Vaccination and natural infection with Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) confer immune protection through distinct mechanisms, however, their effects on Natural Killer (NK) cell responses remain poorly understood, particularly in relation to COVID-19 disease severity. NK cells, key mediat...
Alessandro Frigo, S. Terzoli, Paolo Marzano et al.· Frontiers in Immunology· 0 citations
BACKGROUND
Glioblastoma (GBM) is an aggressive brain tumor and an unmet clinical need due to its invasiveness and therapy resistance. These features are driven by glioblastoma stem-like cells (GSLCs), which exhibit remarkable functional heterogeneity. While transcriptional profiling has helped define this heterogeneity...
C. Barelli, M. Bonfanti, F. Mirabella et al.· Neuro-Oncology· 0 citations
Epigenetics is central to tumorigenesis, but the co-evolution of the cancer epigenome and its microenvironment is severely understudied. Here, we measure chromatin accessibility and transcriptome, at single cell resolution, of a set of normal colon, primary colorectal cancers and metastases, and identify recurrent epig...
Alexandra Livanova, Luca Azzolin, F. Cambuli et al.· bioRxiv· 0 citations
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