Organotypic vascularization improves maturation of human stem cell-derived islets and restores normoglycemia in diabetic mice.
This work generated vascularized PIOs (VPIOs) by co-culturing PIOs with blood vessel organoids (BVOs), resulting in integrated structures with BVOs-derived capillary networks that penetrate into the islet structures that enhance β cell maturation and tissue-specific blood vessel specification in vitro and improves graf...