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Author

Clifford Young

2 papers indexed here

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Oct 2026

Advancing Host Cell Protein Characterization in Monoclonal Antibody Therapeutics: A Nanoparticle-Enriched and High-Sensitivity Mass Spectrometry Approach

This study presents a rapid, sensitive, and high-throughput HCP characterization workflow integrating the Seer Proteograph XT nanoparticle-enrichment platform, the Evosep ONE LC system, and timsUltra AIP mass spectrometer, highlighting the potential of automated nanoparticle enrichment and advanced mass spectrometry fo...

Abdulafeez Akinloye, Sri H. Ramarathinam, Parul Mittal et al. · 0 citations
Sep 2026

Middle-Down Mass Spectrometry Characterization of Monoclonal Antibody Enabled by Electron-Activated Dissociation on a Time-of-Flight Platform: A Case Study of Methionine Oxidation PTM Identification and Quantification

Characterizing post-translational modifications (PTMs) in monoclonal antibody products is critical for ensuring product quality attributes understanding and monitoring. While the bottom-up approach is widely adopted, it suffers from the loss of molecular connectivity and is susceptible to artifact generation. Convers...

Abdulafeez Akinloye, Leigh Donnellan, Parul Mittal et al. · 0 citations

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