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Author

Colby F. Lewallen

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Review Open access Sep 2026

The Biology and Cell Engineering of Retinal Pigment Epithelium Cell Transplantation: Developing a Living Drug.

An overview of RPE biology and function, clinical-grade manufacturing of RPE transplants, quality control considerations, and the use of scaffolds to improve delivery and integration is provided.

Sudipta Mahato, Elena Daniele, Colby F. Lewallen et al. · 0 citations
Open access Aug 2026

Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.

This study develops induced pluripotent stem cell-derived RPE models (iRPE) and identifies two drugs, pioglitazone, a mitochondrial metabolic modulator, and galunisertib, a TGFBR1 inhibitor, as potential therapeutic candidates for multiple ciliopathy subtypes.

Dominik Reichert, Sena Gul, D. Ortolan et al. · 0 citations

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