Author

Congcong Lin

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Oct 2026

Injectable Thermosensitive Hydrogel Synergizes Antibacterial Action with Microenvironment Remodeling in Infected Diabetic Wounds

Chronic wounds represent substantial clinical challenges due to their intricate pathophysiology, characterized by persistent infection, sustained inflammation, and compromised tissue regeneration. To overcome these obstacles, we developed an injectable thermosensitive hydrogel system (MR-NPs-Gels), incorporating engi...

Xiao-Yang Li, Ming Yan, Xiao-Dan Wang et al. · Molecular Pharmaceutics · 0 citations

Aug 2026

Prenylated 4-Hydroxycoumarin derivatives as inducers of CDK4/6-mediated cell cycle arrest: From design and synthesis to in vitro and in vivo evaluation of their anti-breast Cancer activity.

PB1-3 represents a promising prenylated coumarin lead that orchestrates both CDK4/6-Rb cell cycle checkpoint blockade and ROS-dependent mitochondrial apoptosis, offering a valuable scaffold for developing targeted breast cancer therapies, especially for TNBC.

Xinyao Pan, Shiyu Wang, Kaifeng Lai et al. · Bioorganic chemistry (Print) · 0 citations