Microbial production of phenolic acids offers a sustainable alternative to plant extraction, reducing carbon loss and environmental impact. Here, we present a multi-level engineering strategy in Escherichia coli integrating carbon-efficient pathways, enzyme optimization, and subcellular compartmentalization. A synthe...
Binbing Xu, Qin-Yu Guo, Qi Cui et al.· ACS Sustainable Chemistry &a...· 0 citations
Microbial CO₂ assimilation provides a strategy for sustainable biomanufacturing. However, CO₂ reduction requires substantial energy input, while native energy systems are tightly regulated and extensively consumed by endogenous metabolism, limiting assimilation efficiency. Here, we design and construct an orthogonal en...
Short-chain diols (C2-C6) are key platform chemicals widely used in polyesters and polyurethanes; however, their large-scale adoption remains limited by cost, scalability, and process robustness. This review summarizes recent advances in microbial production from an integrated perspective encompassing chassis engineeri...
