Author

Corinna Benz

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Open access Sep 2026

Interconnections with and within the trypanosomal respiratory chain revealed by complexome profiling

This work cataloged the proteins of RC and other mitochondrial complexes in unicellular Trypanosoma, which remodels its RC during its life cycle and revealed interesting interconnections uncovered by the ‘complexome’ to expand the known interactions that the RC engages in to keep the power running in mitochondria.

Corinna Benz, R. Khan, Michael Hammond et al. · bioRxiv · 0 citations

Open access Jul 2026

Trypanosomal MICOS is assembled on non-respiring mitochondrial crista precursors and associates with two integral microproteins

It is demonstrated that all MICOS subunits assemble onto precursor cristae, retaining conserved interactions with both outer and inner membrane protein machineries, establishing that MICOS assembly precedes cellular respiratory competence and expand its interaction landscape in trypanosomatids.

Michala Boudová, Teresa Wagner, Tomáš Bílý et al. · bioRxiv · 1 citation