Author

Courtney L. Smith

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Open access Oct 2026

Nucleoporin 50 rescues hallmarks of TDP-43 proteinopathy in ALS/FTD disease models

Nuclear depletion and cytoplasmic aggregation of RNA-binding protein TDP-43 are common neuropathological hallmarks of the amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) disease spectrum. Although defects in nucleocytoplasmic transport are well-documented in ALS/FTD disease models and patient...

Courtney L. Smith, Bilal Khalil, Alyssa C. Walker et al. · Molecular Neurodegeneration · 0 citations

Open access Aug 2026

Repositioning of polyubiquitin alters the pathologic tau filament structure.

It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al. · Nature Structural & Molecula... · 1 citation