Review
Open access
Jul 2026
At the Crossroads of Synapses and Signaling: The Role of LRRK2 in Neuronal Communication
How LRRK2-dependent trafficking mechanisms regulate key components of synaptic transmission, including glutamatergic and GABAergic receptors, as well as astrocytic transporters are examined, highlighting how disruption of these processes affects neurotransmitter clearance, receptor activation, and ultimately E/I balance.
Angela Di Iacovo, Chiara D’Agostino, Giulia Casoli et al.
· Cellular and molecular neuro... · 0 citations