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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Cui Cui

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Open access Jul 2026

Self-assembling pH-responsive peptide nanoparticles delivering pyrvinium pamoate induce osteosarcoma senescence through CBX4 ubiquitination-mediated inhibition of YAP1 SUMOylation.

A pH-responsive biomineralization-induced peptide self-assembly nanodelivery system (NP@PP) is developed to improve the druggability of PP and reveals a critical role of the CK1α-CBX4-YAP1 signaling axis in senescence-based osteosarcoma therapy and provides a theoretical and practical basis for the development of new n...

Renyi Zhou, Yue Ma, Xu-Dong Liu et al. · 0 citations

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