Author

Cui-Yu Yang

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Open access Sep 2026

Machine learning-based discovery and clinical validation of STX12 and INPP5D as plasma biomarkers for Parkinson’s disease

Despite significant scientific progress in recent years, a notable gap remains in the availability of reliable non-invasive biomarkers for the early diagnosis of Parkinson’s disease (PD). This study aimed to identify and validate novel plasma biomarkers for PD using integrated bioinformatics and machine learning. Trans...

Cui-Yu Yang, Rong Huang, Si-Jun Li et al. · Scientific Reports · 0 citations

Open access Sep 2026

Integrating Target Prediction and Transcriptomic Analysis Identifies the AKR1C2-KRT8 Axis in Rotenone-Induced Dopaminergic Neuron Injury.

Parkinson's disease (PD) is a complex neurodegenerative disorder in which environmental toxins play a critical etiological role. Rotenone, a classical mitochondrial complex I inhibitor used to model PD, exerts its neurotoxicity through incompletely defined downstream molecular networks. Here, we integrated multiple PD...

Jian-He Lin, Lian-Yu He, Jing-Ling Wang et al. · Brain Research Bulletin · 0 citations