Author

Cui-Zhen Zhang

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Open access Sep 2026

deptor disruption induces axonal and behavioral abnormalities through altered cholesterol metabolism in zebrafish.

The mechanistic target of rapamycin (mTOR) signaling pathway is a highly conserved regulator of cellular growth and survival. DEPTOR serves as an endogenous inhibitor of this pathway by directly binding to both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). While DEPTOR is extensively implicated in oncology and p...

Ming-Shan Zhou, Cui-Zhen Zhang, Gang Peng · Neurobiology of Disease · 0 citations

Open access Sep 2026

Deep Learning-Guided Identification and In Vivo Validation of Compact Cis-Regulatory Elements for the Zebrafish Habenula

Background/Objectives: Precise genetic access to the zebrafish habenula remains limited by a scarcity of compact, sequence-defined cis-regulatory elements (CREs). Here, we integrated developmental expression mapping, deep-learning predictions on long-range sequences, and in vivo reporter assays to identify compact regu...

Ze-Ran Li, Shan-Shan Liu, Quan Zhang et al. · Genes · 0 citations