Open access
Oct 2026
CDK9 Degradation Suppresses Gastroesophageal Cancer Growth and Overcomes Radiation Resistance through Chromatin Remodeling and YAP1/TEAD Downregulation.
Gastroesophageal adenocarcinoma (GEAC) remains a highly aggressive malignancy with limited effective targeted therapies. Cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation, has been implicated in oncogenic processes across multiple cancer types; however, its functional role and therapeutic...
Y. Zhang, Mikel Ghelfi, Yu Xue et al.
· Cancer Letters · 0 citations