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Author

Cynthia X. Ma

2 papers indexed here

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Open access Sep 2026

The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology

Quantitative co-clinical imaging provides a powerful framework to link genotype with function by confirming drug delivery, target engagement, pharmacodynamic effects, tumor function and heterogeneity across animal models and patients to advance functional precision medicine (FPM).

K. Shoghi, C. Badea, Donna M. Peehl et al. · 0 citations
Jul 2026

Cathepsin B-Activated Vitamin E Prodrugs Target Cancer Stem Cells and Enhance Chemotherapy Response in Triple-Negative Breast Cancer with Minimal Cardiotoxicity.

Triple-negative breast cancer (TNBC) remains one of the most difficult malignancies to treat owing to high relapse, enrichment of cancer stem cells (CSCs), and constitutive activation of pro-survival signaling such as NF-κB. We conceived a new therapeutic concept-A Priori Activation of Apoptosis Pathways (AAAPT)-design...

Raghu S Pandurangi, M. Tomasetti, Sekar T Verapazham et al. · 0 citations

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