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Author

D. Agard

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2 papers indexed here

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Open access Sep 2026

A tripartite mechanism licenses RNA polymerase import into the phage nucleus

Nucleus-forming jumbo phages import a phage-encoded non-virion RNA polymerase (nvRNAP) into a proteinaceous nucleus, but how it is selected for import is unknown. Here, we identify an import pathway that couples nvRNAP subunit interactions with phage-encoded import factors. Maximal nvRNAP import requires a novel factor...

Claire Y. Kokontis, Deepto Mozumdar, Daphne F. Chen et al. · 0 citations
Open access Aug 2026

Structural and mechanistic analyses reveal collaborative regulation of HSF1 by the Hsp70-Hsp90 chaperone systems

A FRET-based approach to simultaneously monitor HSF1 conformational change and oligomeric state throughout activation and inactivation is developed and previously contradictory view on Hsp90’s role in HSF1 regulation is unify.

T. Owens, K. Schaefer, Trenton M. Peters-Clarke et al. · 0 citations

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