Author

D. Alnaes

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Open access Aug 2026

An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer's Disease Using Neuroimaging, Polygenic Risk, and Cognitive Assessments

Multimodal integration of cognitive, neuroimaging, and polygenic data in the MHS-RWD tool yields strong discrimination for both early diagnosis of dementia and AD differential diagnosis, which could support etiologically informed dementia decisions in real-world settings, with potential utility in primary care.

T. T. Filiz, V. Fominykh, K. Persson et al. · medRxiv · 0 citations

Open access Aug 2026

Lifespan brain structural variation reveals shared organization across mental health conditions

Elucidating the neurobiological basis of neurodevelopmental and psychiatric conditions (NDPCs) remains challenging because brain alterations vary within diagnoses and overlap across them. Whether diverse alterations follow a systematic organization that may reflect shared vulnerabilities remains unknown. Here, we assem...

M. Hettwer, A. Saberi, G. Shafiei et al. · medRxiv · 0 citations