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Sep 2026

Shared Transcriptional Features of Layer 3 Pyramidal Neurons Projecting to the Monkey Dorsolateral Prefrontal Cortex.

OBJECTIVE Layer 3 (L3) pyramidal neurons projecting to the primate dorsolateral prefrontal cortex (DLPFC) convey essential information for core cognitive processes. Alterations in these neurons could contribute to cognitive deficits in schizophrenia. This study was designed to determine whether DLPFC-projecting L3 pyra...

D. Arion, J. Enwright, F. Krienen et al. · 0 citations
Open access Sep 2026

322. Dysregulation of Cav3.1 and Cav1.2 in vulnerable DLPFC pyramidal neurons: a mechanistic link to cognitive disorders

Abstract Background The recently evolved dorsolateral prefrontal cortex (DLPFC) is essential to higher cognition, working memory and abstract thought, with pyramidal cell microcircuits in layer III that are able to excite each other to keep information “in mind” without sensory stimulation1,2. However, these pyramidal...

D. Datta, S. Yang, G. González-Burgos et al. · 0 citations

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