The majority of metabolic pathways rely on the production of activated electrophilic intermediates, e.g., coenzyme-A esters, and their chemical structures and abundances are central to understanding enzyme function and biochemical mechanisms. However, most electrophilic metabolites are lost in traditional metabolomic a...
Allen F. Schroeder, Yan Yu, Ali Turk et al.· ACS Chemical Biology· 0 citations
The distal small intestine has a vital role in host physiology through its regulation of nutrient and fluid homeostasis. Despite being affected in Crohn's disease and serving as a major target for a range of infections, we know relatively little about the complexity of cellular responses and cell-cell communication in...
A. Hart, Maria I. Merolle, Christian A. Howard et al.· Nature Immunology· 0 citations
AIMe (AI Molecule Explorer), a multi-agent neuro-symbolic AI framework that transforms the interpretation of unknown spectra into an omics-scale exploration across the known structural space, providing chemically interpretable annotations, is introduced.
U. U. Acikalin, Dieqiao Feng, Aaron M. Ferber et al.· bioRxiv· 0 citations
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