Lipids are essential for brain structure and function, contributing to membrane integrity, synaptic activity, signal transduction, and energy metabolism. Converging evidence from human genetics, epidemiology, lipidomics, and neuroimaging indicates that disrupted lipid homeostasis is an early and biologically rele...
L. Berliocchi, M. Grimm, Tobias Hartmann et al.· BMC Medicine· 0 citations
DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.· Nature Neuroscience· 1 citation
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