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Review Open access Sep 2026

Targeting lipid homeostasis for preventive intervention in brain aging and Alzheimer’s disease

Lipids are essential for brain structure and function, contributing to membrane integrity, synaptic activity, signal transduction, and energy metabolism. Converging evidence from human genetics, epidemiology, lipidomics, and neuroimaging indicates that disrupted lipid homeostasis is an early and biologically rele...

L. Berliocchi, M. Grimm, Tobias Hartmann et al. · 0 citations
Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence

DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · 1 citation

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