Strategic Application of New Approach Methodologies (NAMs) in Fragrance Ingredient Safety Assessment: Integration of In Vitro, In Silico, and Exposure-Based Approaches in RIFM Evaluations.
New Approach Methodologies (NAMs) are transforming toxicological risk assessment by providing human-relevant, non-animal approaches for hazard identification, exposure assessment, and safety evaluation. This manuscript presents an overview of the Research Institute for Fragrance Materials (RIFM) New Approach Methodolog...