Open access
Oct 2026
Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort.
DNA methylation (DNAm) plays a critical role in Alzheimer's disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer's Dis...
G. Miao, Cheng Gao, Lei Yu et al.
· Nature Aging · 0 citations