Author

D. Botelho

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Review Oct 2026

An Overview of In Vitro Genotoxicity Testing Strategies for Fragrance Materials: Addressing False Positives and Advancing Non-Animal Approaches.

The European Union's ban on in vivo genotoxicity testing for cosmetic ingredients (Directive 2003/15/EC), followed by the Scientific Committee on Consumer Safety (SCCS) 7th amendment, has created an urgent need for robust, non-animal genotoxicity testing strategies. Standard regulatory in vitro assays - including the A...

Yax Thakkar, D. Botelho, A. M. Api · Food and Chemical Toxicology · 0 citations

Review Sep 2026

Strategic Application of New Approach Methodologies (NAMs) in Fragrance Ingredient Safety Assessment: Integration of In Vitro, In Silico, and Exposure-Based Approaches in RIFM Evaluations.

New Approach Methodologies (NAMs) are transforming toxicological risk assessment by providing human-relevant, non-animal approaches for hazard identification, exposure assessment, and safety evaluation. This manuscript presents an overview of the Research Institute for Fragrance Materials (RIFM) New Approach Methodolog...

I. Lee, A. M. Api, A. Bartlett et al. · Food and Chemical Toxicology · 1 citation