Author

D. Braun

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Open access Sep 2026

75 Transcriptional Correlates of ARNT Expression and its Impact on Survival Outcomes in Clear-Cell Renal Cell Carcinoma (ccRCC)

Across three cohorts, higher ARNT expression correlated with higher BHS, and a consistent correlation was observed between ARNT and EPAS1 and HIF1A expressions, and a consistent correlation was observed between ARNT and EPAS1 expressions.

Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad et al. · The Oncologist · 0 citations

Open access Sep 2026

8 Single Cell Transcriptomic Investigation of Renal Cell Carcinoma (RCC) Reveals Tissue Resident Memory Exhausted CD8+ T Cell Signature Associated with Resistance to Immune Checkpoint Inhibition (ICI)

Abstract Background The current standard of care for advanced RCC is ICI-based combination therapies. However, most patients with advanced RCC develop disease progression despite ICI treatment, suggesting a lack of durable immune response. Although a lack of T cell infiltration or the presence of non-tumor-reactive “by...

Rishabh Rout, S. Kashima, M. Hugaboom et al. · The Oncologist · 0 citations

Open access Sep 2026

51 Discovery of Exhausted CD8+ T-cell States Associated with Clinical Outcomes in Renal Cell Carcinoma

Abstract Background Therapeutic resistance to immune checkpoint inhibitors (ICIs) and antiangiogenic therapies remains a significant clinical challenge in advanced renal cell carcinoma (RCC). The prognostic value of CD8+ T-cell infiltration—a central player in cancer immunity—is often equivocal across RCC studies, supp...

Zhao-Chen Ye, Soki Kashima, Rishabh Rout et al. · The Oncologist · 0 citations