D. Cao

Unreacted RSV Polymerase Structures Expand the Post-Translocation Landscape of the Nucleotide Addition Cycle

Two cryo-electron microscopy structures of unreacted RSV polymerase bound to a post-translocation RNA product mimic are reported, demonstrating that the canonical architecture can be recovered independently of nucleotide incorporation and highlighting unreacted state-matched complexes as a complementary approach to rea...