Open access
Aug 2026
The VPS35 p.A320V variant segregates with Parkinson's disease in a pesticide-exposed family
While VPS35 p.A320V co-segregated with PD in this family, it did not exhibit the characteristic LRRK2-associated biomarker signature observed in VPS35 p.D620N carriers, it is possible that p.A320V exerts a subtle effect on VPS35 function that was not captured by the assays performed and that chronic pesticide exposure contributed to disease penetration in this pedigree.
S. Glendinning, J. A. Arbelo Gonzalez, L. Diaz-Feliz et al.
· medRxiv · 0 citations