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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

D. Conole

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Open access Sep 2026

Affinity selection mass spectrometry screening discovers new COP1 peptide binders

Targeting E3 ubiquitin ligases with chemical probes remains a major challenge, despite their central roles in cellular regulation and disease. Constitutive photomorphogenic 1 (COP1) is an E3 ligase whose complex, adaptor-dependent biology has made its selective targeting difficult. Here, we develop a peptide-based affi...

Harsha Negi, Noor Radhi, Nicolas Schiff et al. · 0 citations
Jul 2026

Abstract B027: CRISPR screens identify thioredoxin reductase 1 as a target for inducing disulfidptosis in IDH1 -mutant glioma models

It is shown that glioma models are dependent on TXNRD1 for survival, but acquire adaptive antioxidant changes to survive TXNRD1 loss, and the underlying mechanism using thioredoxin reductase 1 (TrxR1) inhibitors and TXNRD1 knockout (KO) models is validated.

S. O’Brien-Gortner, Dinar Rani K, D. Conole et al. · 0 citations

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