Open access
Sep 2026
Light-Mediated Desulfurization of Peptides in Multi-Well Format for Combinatorial Library Synthesis
Native chemical ligation (NCL) combined with post-ligation desulfurization is a powerful strategy for the chemical joining of unprotected peptide segments to form larger polypeptides or to synthesize head-to-tail cyclized peptides. However, a simple, robust, and safe desulfurization protocol suitable for high-throughpu...
Esther Arentoft Jacobsen, Julian Lava, A. Thorseth et al.
· Molecules · 0 citations