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Although signs and symptoms of heart failure (HF) have been described since ancient times, and the term has evolved throughout history, there are still unanswered questions concerning its pathophysiology and best treatment options [...].
The gut microbiome may act as a dynamic mediator linking estrogen decline with metabolic and systemic aging after menopause, however, causality, individual variability, and clinical translation remain insufficiently established.
Individualized, multidisciplinary Heart Team planning, including a dedicated biventricular guidewire strategy, can simplify sequential transcatheter treatment of multivalvular disease in patients with pre-existing intracardiac hardware.
HRRI is significantly reduced in HFpEF and distinguishes patients with and without heart failure, and shows associations with echocardiographic markers of diastolic and longitudinal systolic dysfunction, exercise capacity, and H2FPEF score.
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