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Open access Sep 2026

BRAFV595E mutation detected across the disease spectrum from non-neoplastic urothelium to invasive urothelial carcinoma in dogs.

Objective The goal was to determine the presence of a driver mutation in dogs with and without detectable cancer to set the stage for future cancer prevention research exploiting processes that inhibit cancer development in the presence of such mutations. The objective was to detect the v-raf murine sarcoma viral oncog...

D. Dhawan, Mario F. Sola, Jennifer B. Nelson et al. · 0 citations
Open access Sep 2026

The Same, but Different: Shared Hallmarks and Divergent Drivers in Adult, Pediatric and Canine Glioma

Malignant gliomas are the most common primary brain tumors, with dismal outcomes. Pet dogs have been proposed as a valuable model for studying gliomas. Here, we compare spontaneously occurring gliomas from adult and pediatric human and canine patients, focusing on the tumor microenvironment (TME) and the canonical path...

R. Bentley, S. Utturkar, Harish Kothandaraman et al. · 0 citations

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