Author

D. Dickson

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Open access Sep 2026

Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes

Abstract Clinical syndromes of frontotemporal dementia present both distinct and overlapping neuroimaging abnormalities and, consequently, domains of impairment. The aim of this study was to determine how well covariance patterns from multiple neuroimaging modalities discriminate across clinical frontotemporal dementia...

Irene Sintini, Neha Singh-Reilly, Farwa Ali et al. · Brain Communications · 0 citations

Open access Aug 2026

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

TAR DNA-binding protein of 43 kDa (TDP-43) is often found in the brains of patients with Alzheimer’s disease (AD), where it co-occurs with amyloid β plaques and tau neurofibrillary tangles, and associates with accelerated cognitive decline and brain atrophy. TDP-43’s function of repressing the inclusion of cryptic exon...

Madison M. Reeves, Sara Aviles Carpintero, M. Zanovello et al. · Alzheimer's Research & Thera... · 0 citations

Open access Aug 2026

Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease

A hypothetical model of dynamic brain gene expression changes that track with progressive Alzheimer’s disease proteostasis is proposed and found that a beneficial brain biochemical state of higher total tau and lower phospho-Tau is associated with increased levels of synaptic, DNA damage/repair, nucleic acid metabolism...

Stephanie R. Oatman, Zachary S. Quicksall, Xue Wang et al. · Brain Communications · 0 citations