Author

D. Uti

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Review Open access Sep 2026

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer stem cells (CSCs) are increasingly recognized as metabolically plastic subpopulations within malignant tissues that drive tumor initiation, metastatic dissemination, and relapse after therapy. Although traditional models of cancer metabolism have emphasized aerobic glycolysis, CSCs rarely exhibit a single, clear...

D. E. Uti, E. U. Alum, J. Egbung et al. · Cancer Medicine · 0 citations

Review Aug 2026

Engineered exosomes for CRISPR/Cas delivery to overcome oncogene-driven drug resistance.

The goal of this review is to outline a realistic pathway featuring proof-of-concept research, through discoveries to the creation of manufacturable, safe, and effective exosome/CRISPR therapeutics that can trigger durable therapeutic responses in resistant malignancies.

D. E. Uti · Experimental Cell Research · 0 citations

Review Aug 2026

Synthetic biology strategies for engineering microbial therapeutics in metabolic diseases and cancer.

This review highlights chassis selection, circuit architectures, applications for metabolic diseases and cancer, metabolic bottlenecks, and future directions for precision microbial therapeutics for metabolic disorders and oncology.

B. Onoja, S. Agada, Waheeb S. Aggad et al. · Microbiology Research · 0 citations