Author

D. Eisel

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Open access Sep 2026

Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T cell immunity

Preclinical results validate a rational design approach to overcome the limitations of IL-2 therapy and support the clinical evaluation of Alb–IL-2var RNA-LNP for solid cancers.

Mathias Vormehr, L. Kranz, A. Muik et al. · Science Advances · 0 citations

Open access Jul 2026

Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells.

This work shows that short, chemically synthesized RNA oligonucleotides lacking some or all of these features are efficiently translated when they encode epitopes recognized by CD8+ T cells and introduces the possibility that defective or supposedly non-coding RNA may encode human and murine major histocompatibility co...

Julia Frei, D. Eisel, N. Jarzębska et al. · Nature Biomedical Engineerin... · 1 citation