Tissue-Specific Epigenetic Drift in Parkinson’s Disease: A Multi-Region DNA Methylation Meta-Analysis
IntroductionParkinson’s disease (PD) is a neurodegenerative disorder whose genetics explains only part of the disease risk, suggesting the involvement of non-genetic factors. Epigenetic-drift, defined as the accumulation of stochastic epigenetic mutations (SEMs) in DNA, has been implicated in other neurodegenerative di...