Methylene and difluoromethylene uridine bisphosphonate carbagalactose were designed and synthesized as stable uridine diphosphate-galactose (UDP-Gal) mimics for probing α-1,4-galactosyltransferase (A4GALT). In these analogues, the labile glycosidic and pyrophosphate linkages of UDP-Gal are replaced by chemically and en...
Jian-Yun Guo, Nicky de Koster, Bob van Puffelen et al.· Organic Letters· 0 citations
Norovirus is a leading cause of global acute gastroenteritis, yet the mechanisms underlying its replication remain incompletely understood. As a positive-sense single-stranded RNA (+ ssRNA) virus, norovirus utilizes a nucleotidylated viral protein (VPg) as a primer for synthesis of its genomic and subgenomic mRNAs. In...
Bob van Puffelen, L. X. Neves, Roy Steneker et al.· RSC Chemical Biology· 0 citations
This study chemically synthesized two hitherto undescribed biosynthetic intermediates that were predicted based on bioinformatic analyses, CDP-threonine and CDP-N-methylthreonine, and showed that they are involved in the Type A PGM biosynthesis, as evidenced by mass spectrometric analyses of extracts of a set of C. dif...
P. Hensbergen, Bob van Puffelen, Nina Musch et al.· Proceedings of the National...· 0 citations
The stereoselective synthesis of deoxynucleotide-phospho-ADPr (dN-P-ADPr) probes are reported, representing native fragments of terminal DNA-ADPr, showing that these enzymes exhibit an absolute preference for the native-like α-anomer, independent of the identity of the adjacent DNA nucleobase, suggesting that substrate...
Lingxiao Liu, Yang Lu, Zongxing Yu et al.· Journal of the American Chem...· 0 citations
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