Review
Open access
Sep 2026
Large serine recombinase-mediated gene insertion for high-throughput screens: advantages, design principles, and applications
This review highlights large serine recombinases (LSRs) as highly efficient, single-enzyme alternatives for unidirectional, site-specific integration of large payloads with deterministic junctions, and surveys targeted genomic integration strategies and detail best practices for implementing recombinase-based landing p...
A. Martella, Kenneth A. Matreyek, D. Fisher
· Nucleic Acids Research · 0 citations