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Open access Aug 2026

Early cardiac proteomic profiling in a long-latency doxorubicin cardiomyopathy model exhibits sexual dimorphism for cardioprotection

Anthracycline-induced cardiotoxicity remains a major limitation in cancer therapy, with substantial inter-individual variability in susceptibility, including documented sex differences. However, the molecular basis underlying these disparities remains incompletely understood. In this study, we employed large-scale data...

Sogol Sedighi, Li-Jun Chen, Yue-Fen Wang et al. · 0 citations
Open access Aug 2026

Loss of O-GlcNAc transferase activity impairs the dynamic formation of protective stress granules in ischemic cardiomyocytes

Abstract Stress granules are transient biomolecular condensates of proteins and RNA formed during stress. Stress granules support cell survival by sequestering components of the translational machinery, suppressing pro-apoptotic signaling, and conserving cellular resources. O-GlcNAcylation, a dynamic modification of cy...

Hannah C. Swimm, Wen-Xi Zhang, Y. Mallikarjun et al. · 0 citations

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