Reduced Cumulative Post-Transplant Cyclophosphamide Exposure Is Associated with Increased Acute and Chronic Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation.
BACKGROUND Post-transplant cyclophosphamide (PTCy) is conventionally administered at a cumulative dose of 100 mg/kg for graft-versus-host disease (GVHD) prophylaxis after allogeneic hematopoietic cell transplantation (allo-HCT). In clinical practice, cumulative PTCy exposure may be reduced because of institutional prot...