Author

D. Gibbons

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Open access Aug 2026

Multi-organ aging quantified from routine chest CT predicts chronic disease risk and mortality

Biological aging occurs heterogeneously across individuals and organs. However, current measures of biological age incompletely capture organ-specific differences in health and disease risk. Because chest CT visualizes multiple thoracic organs, it offers an opportunity to quantify structural aging across organ systems....

J. Sato, M. Salehjahromi, A. Zafar et al. · medRxiv · 0 citations

Open access Sep 2026

Distinct Spatial Immune Architectures in Tumor and Tumor-Adjacent Tissues of Early-Stage Non-Small Cell Lung Cancer

Background Lung cancer remains the leading cause of cancer-related deaths in the United States with over 124,000 estimated deaths for 2026. Previous studies have found that tumor-adjacent lung tissues may provide additional insight into the immune microenvironment of early-stage NSCLC. Methods Multiplex immunofluoresce...

Isabella Polic, Claudio J. Arrechedera, Jared K. Slone et al. · bioRxiv · 0 citations

Open access Jul 2026

The genomic landscape and treatment outcomes associated with CDKN2A/MTAP loss in patients with non-small cell lung cancer.

INTRODUCTION Homozygous deletion of 9p21, containing CDKN2A/B and MTAP (CMdel), underlies emerging therapeutic strategies including PRMT5/MAT2A inhibition. The clinicogenomic context and treatment outcomes of CMdel in NSCLC remain incompletely defined. METHODS We analyzed Tempus Lens records with paired DNA/RNA seque...

N. Vokes, J. Symons, Brooke Rhead et al. · Clinical Cancer Research · 0 citations