Review
Open access
Aug 2026
HIV-1 Tat and gp120 as key drivers of neurodegeneration in the central nervous system
Converging data achieved from in vitro models, Tat and gp120-transgenic mice, post-mortem tissue, and cerebrospinal fluid biomarkers indicate that these viral proteins contribute to frontostriatal atrophy and hybrid HAND-AD phenotypes increasingly observed in aging HIV patients.
R. Cecchetto, Erica Diani, V. Lotti et al.
· Frontiers in Microbiology · 0 citations