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Author

D. Hamilton

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Open access Aug 2026

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

This work identifies VCP as a druggable node for host-directed immunomodulation and highlights SKI-II as a prototype small molecule that boosts host tolerance to infection, thereby validating the C. elegans-based screening platform for discovering immunomodulators active in mammalian systems.

Li-Yang Zhang, Kai Ye, Charilaos Dellis et al. · 0 citations

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