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D. Harrison

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Open access Sep 2026

Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth

A striking biological asymmetry is identified whereby female fetuses reduce their demands on the mother in response to Phlda2 loss-of-imprinting, whereas male fetuses do not, which is linked to sex-specific reproductive strategies in mammals in response to prenatal adversity.

A. Chibnall, D. Harrison, E. Lysikova et al. · 0 citations

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