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D. Holland

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Review Open access Sep 2026

From Reduction to Replacement: Challenges and Proposed Solutions for Animal-Free Safety Assessment of Hydrocarbon UVCB Substances

Highlights • UVCB substances derived from petroleum and renewable feedstocks are a category of complex substances spanning a continuum of hydrocarbon distributions, with well-established hazard profiles.• Read-across and predictive models developed based on historical datasets have been extensively used to reduce anima...

D. Holland, Louise Camenzuli, L. Kamelia et al. · 0 citations

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