Summary The COVID-19 crisis is now over, but additional viral strains of SARS-CoV-2 that evade immunity are continuously emerging. We explored the design, evaluation, and optimization of anti-sense oligonucleotides (ASOs) targeting SARS-CoV-2 RNA, with the aim of providing a scalable strategy capable of responding to e...
Greta Gallo, L. Donnici, L. S. Colley et al.· iScience· 0 citations
Using in-house rRNA sequencing, it is found that C. auris rRNA displays substantial divergence, including the lowest 18S rRNA identity among the pathogenic Candida species examined and an unusual substitution at a functionally important nucleotide in helix h31 of the small subunit P-site region.
A. Atamas, A. Stetsenko, D. Incarnato et al.· Structure· 0 citations
Recent advances in RNA chemical probing, sequencing, and computational deconvolution technologies are reviewed, and how resolving RNA structural ensembles with increasingly high resolution will likely reveal new therapeutic opportunities to selectively target functional RNA heterogeneity is discussed.
Anthony M. Mustoe, D. Incarnato· Current Opinion in Structura...· 0 citations
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