Vascularized Composite Allotransplantation (VCA) requires immunosuppression to prevent allosensitization and subsequent allograft rejection. This study evaluated the prevalence, characteristics, and clinical implications of donor-specific antibodies (DSA) in VCA recipients. Thirty-seven VCA recipients (median age 32.5 ...
Xavier Charmetant, Gaelle Wehrlen, Jean Kanitakis et al.· Transplant Immunology· 0 citations
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro....
Johanna Matilainen, Sanni Foster, Viivi Berg et al.· Journal of Extracellular Bio...· 1 citation
Abstract Kidney transplantation is the optimal treatment for end-stage renal disease, yet long-term graft survival remains limited by allograft rejection. While T and B cells and donor-specific antibodies (DSA) have been the main focus, accumulating evidence indicates that natural killer (NK) cells play a significant d...
Anna Skotny, P. Poznański, K. Kościelska-Kasprzak et al.· Archivum Immunologiae et The...· 0 citations
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