Open access
Aug 2026
Priming Cells with Modulators of Cellular Signaling Ensures Enhanced Selectivity of HSPG-Specific Protein–Drug Conjugate Delivery
TriFHS-MMAE is reported, the first multivalent PDC specifically targeting heparan sulfate proteoglycans overexpressed by pancreatic cancer cells, which induces ultrafast and highly efficient aggregation-dependent endocytosis (ADE) of HSPGs.
Aleksandra Chorążewska, Krzysztof Ciura, M. Milczarek et al.
· Journal of the American Chem... · 0 citations